Foster an environment for a legal function that adds strategic value to the organization by proactively implementing business-oriented solutions within the framework of the companys risk tolerance profile;

Serve as trusted advisor and confidant to Karyopharms Board of Directors, Chief Executive Officer and President/Chief Scientific Officer;

Lead all legal activities, including corporate law, SEC filings and compliance, capital markets and financial transactions, business partnerships and other strategic collaborations, litigation, contracts, including clinical trial agreements, corporate governance, employment and human resources activities and general legal support of all other business activities;

Manage multiple direct reports to provide exceptional subject matter expertise across the sales, G&A and R&D functions;

Manage a diverse set of external counsel;

Provide legal support regarding business development transactions, including mergers, acquisitions, divestitures, licensing and collaborations. This includes support of due diligence, transaction negotiation and drafting, and ongoing post-closing legal support, as needed;

Support commercial activities and FDA/other regulatory body compliance;

Support the commercial organization and investor relations/public relations teams by providing legal oversight in all external communications;

Provide company-wide guidance on all Karyopharm business activities;

Support operational activities for parent and subsidiary companies, including intercompany transactions, and compliance with local regulations,

Acts as Corporate Secretary for all matters, including Board of Directors and committee meetings as well as providing thorough and thoughtful feedback to the Board.


JD from top tier accredited law school; MBA or other advanced degree preferred

15+ years of related experience within a top tier law firm and/or public life sciences company;

Strong securities and corporate governance experience, including demonstrated knowledge of applicable securities law;

Significant experience coordinating filings related to and advising clients regarding compliance with a U.S. securities laws;

Experience managing litigation preferred, including securities class action and patent/product litigation;

Experience in managing business development process from opportunity assessment through post-closing support;

Team player, energetic, able to handle stress and high volume of work;

Strong written verbal and communication skills;

Superior organizational skills and attention to detail; ability to adapt to changing priorities; and

Possess a good blend of strategic and operational experience with the ability to see the big picture and dive into details;

Can negotiate skillfully in touch situations with both internal and external groups. Should be both direct and diplomatic;

Communicates results, outcomes and information appropriately with regard to business needs and potential impact in a timely fashion and can effectively present ideas and get buy-in;

Comprehensive knowledge of Microsoft Word, Excel, PowerPoint


Karyopharm Therapeutics is a global commercial-stage pharmaceutical company focused on the discovery and development of novel first-in-class drugs directed against nuclear transport targets for the treatment of cancer and other major diseases.

Karyopharm Therapeutics Inc. (the “Company”) is an equal opportunity employer. All qualified applicants will be considered without regard to age, race, color, sex, religion/creed, national origin, marital status, ancestry, citizenship, military, reservist or veteran status, pregnancy, sexual orientation or preference, gender identity, gender expression, physical or mental disability, genetic predisposition or carrier status, or any other category protected under applicable federal, state or local law. Consistent with its obligations under applicable law, the Company will make reasonable accommodations for qualified individuals with disabilities. If you require an accommodation in the application process, please contact a member of the Companys Human Resources department.

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